C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/18 (2006.01) A61K 38/18 (2006.01) A61K 39/395 (2006.01) C07H 21/00 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C07K 14/495 (2006.01) C07K 14/71 (2006.01) C07K 16/28 (2006.01) C12N 5/10 (2006.01) G01N 33/567 (2006.01) G01N 33/74 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2111853
The invention relates to a family of substantially pure, receptor like TGF- .beta.1 binding glycoproteins. These molecules are characterized by molecular masses of 160 kd, 70-80 kd, and 30-40 kd as determined by SDS-PAGE, and the ability to bind the TGF-.beta.1 molecule. This family of molecules is useful in identifying and/or quantifying TGF-.beta.1 in a sample, as well as inhibiting its effect on cells. Also described are nucleic acid sequences which code for the protein monomer making up the molecules.
Heldin Carl-Henrik
Hellman Ulf
Ichijo Hidenori
Miyazono Kohei
Ronnstrand Lars
Ludwig Institute For Cancer Research
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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