C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/18 (2006.01) C07H 21/02 (2006.01) C07K 14/47 (2006.01) C07K 14/495 (2006.01) C12N 5/10 (2006.01)
Patent
CA 2076979
Purified protein known as platelet TGF-.beta.1-BP (transforming growth factor- .beta.1-binding protein) is described. The protein is useful for purposes such as the production of antisera which is useful in identifying complexes containing the binding protein, as well as in formation of labeled probes itself. Also described is purified DNA which expresses the protein, as well as messenger RNA translated into the protein. The protein contains 16 epidermal growth factors (EGF) like repeats, and 3 repeats not found in other proteins. The DNA for the protein is found to contain consensus sequences for hydroxylation of asparagine/aspartic acid residues, and, in the purified protein beta hydroxylated asparagine residues were found.
Protéine purifiée connue sous le nom de TGF-beta1-BP protéine liant le facteur de croissance transformant beta1 plaquettaire. Cette protéine est notamment utilisée pour la production d'anti-sérums servant à identifier des complexes contenant la protéine liante, ainsi que pour la formation de sondes marquées. Une description est également donnée d'un A.D.N. purifié qui exprime la protéine, ainsi que d'un A.R.N. messager transmis dans la protéine. La protéine contient 16 répétitions analogues aux facteurs de croissance épidermique (EFG), et 3 répétitions qui n'ont pas été trouvées dans d'autres protéines. On a observé que l'A.D.N. de la protéine contient des séquences consensuelles d'hydroxylation de résidus d'asparagine/acide aspartique. En outre, on a trouvé des résidus d'asparagine bêta-hydroxylatée dans la protéine purifiée.
Claesson-Welsh Lena
Heldin Carl-Henrik
Hellman Ulf
Kanzaki Tetsuto
Miyazono Kohei
Ludwig Institute For Cancer Research
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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