Substituted 1 , 1, 2 - triphenylbutenes and their use in the...

Details Substituted 1 , 1, 2 - triphenylbutenes and their use in the... Substituted 1 , 1, 2 - triphenylbutenes and their use in the...

C - Chemistry, Metallurgy

07

D

C07D 295/088 (2006.01) A61K 31/135 (2006.01) A61K 31/40 (2006.01) C07B 59/00 (2006.01) C07C 217/18 (2006.01) C07C 217/20 (2006.01) C07D 295/092 (2006.01) A61K 43/00 (1990.01) A61K 49/02 (1990.01)

Patent

CA 2134772

2134772 9322275 PCTABScor01 Compounds of general formula (2) wherein n is an integer of from 3 to 10, the iodo substituent is in the 3- or 4- position and R1 and R2, which may be the same or different, represent C1-3 alkyl, especially methyl or ethyl, groups or R1 represents a hydrogen atom and R2 a C1-3 alkyl group or R1 and R2 together with the nitrogen atom to which they are attached represent a saturated heterocyclic group, especially a pyrrolidino group, in the form of their free bases or pharmaceutically acceptable acid addition salts are potent anti-oestrogenic compounds useful for treatment of oestrogen-dependent cancers, especially breast cancers. Compounds where the iodine atom is radioisotopic are useful in radiotherapy or gamma ray imaging of these cancers.

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