Substituted 1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic...

Details Substituted 1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic... Substituted 1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic...

C - Chemistry, Metallurgy

07

D

C07D 209/70 (2006.01) A61K 31/403 (2006.01) A61P 37/00 (2006.01) C07D 209/88 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2730500

The present invention relates to certain substituted 1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl) acetic acid derivatives of Formula (Ia) and pharmaceutically acceptable salts thereof, which exhibit useful pharmacological properties, for example, as agonists of the S1P1 receptor. Also provided by the present invention are pharmaceutical compositions containing compounds of the invention, and methods of using the compounds and compositions of the invention in the treatment of S1P1 receptor-associated disorders, for example, psoriasis, rheumatoid arthritis, Crohn's disease, transplant rejection, multiple sclerosis, systemic lupus erythematosus, ulcerative colitis, type I diabetes, acne, microbial infections or diseases and viral infections or diseases.

Cette invention concerne certains dérivés de lacide 1,2,3,4-tétrahydrocyclopenta[b]indol-3-yle acétique substitué de formule (Ia) et leurs sels pharmaceutiquement acceptables, présentant des propriétés pharmacologiques utiles, par exemple, comme agonistes du récepteur S1P1. Linvention concerne également des compositions pharmaceutiques contenant les composés de linvention, et des méthodes dutilisation des composés et des compositions de linvention dans le traitement des troubles associés au récepteur S1P1, par exemple, le psoriasis, la polyarthrite rhumatoïde, la maladie de Crohn, le rejet du greffon, la sclérose en plaques, le lupus érythémateux systémique, la rectocolite hémorragique, le diabète de type I, lacné, les infections ou les maladies microbiennes et les infections ou les maladies virales.

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