Substituted 1,2,4-triazolo[1,5-a] triazines as bronchodilators

Details Substituted 1,2,4-triazolo[1,5-a] triazines as bronchodilators Substituted 1,2,4-triazolo[1,5-a] triazines as bronchodilators

C - Chemistry, Metallurgy

07

D

167/211, 260/249

C07D 487/04 (2006.01) A61K 31/53 (2006.01)

Patent

CA 1311753

ABSTRACT OF THE DISCLOSURE: The invention relates to bronchodilator compounds of formula I Image (I) wherein R2 is hydrogen, lower alkyl, or phenyl; R5 is lower alkyl; and R7 is methoxy, methylthio or Image wherein X is independently oxygen, sulfur, methylene alkyl (-CH2-), imido (-NH-) or N-lower alkylimido (-N-); and pharmaceutically acceptable acid-addition salts are disclosed. Pharmaceutical formulations comprising such compounds and pharmacological methods of using such compounds are also disclosed.

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