Substituted 1,3,4-benzotriazepines, a method of preparing...

Details Substituted 1,3,4-benzotriazepines, a method of preparing... Substituted 1,3,4-benzotriazepines, a method of preparing...

C - Chemistry, Metallurgy

07

D

260/238.1

C07D 255/04 (2006.01)

Patent

CA 1227196

Abstract of the disclosure: This invention relates to substituted-1,3,4-benzo- triazepines of the formula Image wherein X and Y are each independently hydrogen, lower- alkyl, halogen, lower alkoxy, nitro and hydroxyl; R1 and R3 are each independently hydrogen or alkyl; R2 is hydrogen, lower alkyl, cycloalkyl lower alkyl, phenyl, aryl lower alkyl, hydroxyl and sulfhydryl; m and n are each independently integers of 0 or 1 and when m is 0, n is 1 and vice-versa; and p and q are independently integers of 1 or 2. Also included in the invention are the substituted-1,3,4-benzotriazepine derivatives of tauto- meric form when the substituent for R1 and/or R3 in the above formula is hydrogen. The invention relates further to a process for the preparation of the mentioned compounds and their use as antihypertensive agents.

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