Substituted 1, 3-oxathiolanes and substituted 1,...

Details Substituted 1, 3-oxathiolanes and substituted 1,... Substituted 1, 3-oxathiolanes and substituted 1,...

C - Chemistry, Metallurgy

07

D

C07D 411/04 (2006.01) A61K 31/435 (2006.01) A61K 31/495 (2006.01) A61K 31/53 (2006.01) C07D 327/04 (2006.01) C07D 339/06 (2006.01) C07D 409/04 (2006.01) C07D 471/04 (2006.01) C07D 473/00 (2006.01) C07D 487/04 (2006.01) C07F 7/08 (2006.01) C07F 7/18 (2006.01) C07H 21/00 (2006.01)

Patent

CA 2095613

This invention relates to novel substituted 1,3-oxathiolanes and substituted 1,3-dithiolanes of formula (1) wherein X is S, S=O, or SO2; Y is O, S, S=O, or SO2; R1 is hydrogen, trisubstituted silyl, substituted or unsubstituted C1-6 alkyl, substituted or unsubstituted aralkyl, or substituted or unsubstituted C1-16 aryl; and R2 is a purine or pyrimidine base or an analogue or derivative thereof; and pharmaceutically acceptable derivatives thereof. This invention also relates to processes for preparing these compounds, intermediates useful in their preparation, to pharmaceutical compositions containing them and to the use of these compounds as antiviral agents.

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