Substituted 1,4-dihydropyridine compounds as bradykinin...

Details Substituted 1,4-dihydropyridine compounds as bradykinin... Substituted 1,4-dihydropyridine compounds as bradykinin...

C - Chemistry, Metallurgy

07

D

C07D 417/06 (2006.01) A61K 31/497 (2006.01) A61P 11/06 (2006.01) A61P 29/00 (2006.01) C07D 401/06 (2006.01) C07D 401/14 (2006.01) C07D 413/06 (2006.01) C07D 413/14 (2006.01) C07D 417/12 (2006.01) C07D 417/14 (2006.01) C07D 451/02 (2006.01) C07D 451/04 (2006.01) C07D 453/02 (2006.01)

Patent

CA 2327946

This invention provides a compound of the formula (I): (see formula I) or the pharmaceutically acceptable salts thereof wherein A is independently halo; Y is -(CH2)m-, -C(O)- or -S(O)-; R1 and R2 are independently C1-4 alkyl; R3 is C7-9 bicycloalkyl, C5-7 azacycloalkyl or C7-9 azabicycloalkyl, the C7-9 bicycloalkyl, C5-7 azacycloalkyl or C7-9 azabicycloalkyl being optionally substituted with one, two or three substituents are independently selected from oxo, hydroxyl, C1-4 alkyl, C1-4 alkyloxy, C1-4 alkyl-carbonyl, formyl, C1-4 alkylenedioxy, and phenyl-C1-4 alkyl; R4 is thiazolyl, imidazolyl or oxazolyl, the thiazolyl, imidazolyl or oxazolyl being optionally substituted with one or two substituents independently selected from C1-4 alkyl and halo; R5 is hydrogen or C1-4 alkyl; m is 0, 1 or 2; and n is 0, 1, 2, 3, 4 or 5. These compounds are useful for the treatment of medical conditions mediated by bradykinin such as inflammation, allergic rhinitis, pain, etc. This invention also provides a pharmaceutical composition comprising the above compound.

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