Substituted 1,4-thiazepine and analogs and their use as...

Details Substituted 1,4-thiazepine and analogs and their use as... Substituted 1,4-thiazepine and analogs and their use as...

C - Chemistry, Metallurgy

07

D

C07D 281/06 (2006.01) A61K 31/55 (2006.01) A61P 35/00 (2006.01) C07D 281/10 (2006.01) C07D 405/04 (2006.01) C07D 417/04 (2006.01) C07D 417/14 (2006.01) C07D 513/04 (2006.01) C07D 513/14 (2006.01)

Patent

CA 2406271

The present invention is directed to substituted 1,4-thiazepine and analogs thereof, represented by the general Formula (I): wherein the dashed lines, A1, A2, A3, X1 and R1 are defined herein. The present invention also relates to the discovery that compounds having Formula I are activators of capases and inducers of apoptosis. Therefore, the activators of caspases and inducers of caspases and inducers of apoptosis of this invention can be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.

La présente invention concerne une 1,4-thiazépine substituée et ses analogues, représentés par la formule générale (I) : dans laquelle les lignes en pointillés A?1¿, A?2¿, A?3¿, X?1 ¿et R?1 ¿sont définies ici. La présente invention concerne également la découverte selon laquelle les composés représentés par la formule I sont des activateurs de capases et des inducteurs d'apoptose. Par conséquent, les activateurs de caspases et inducteurs d'apoptose de l'invention peuvent être utilisés pour induire la mort cellulaire dans une variété de conditions cliniques dans lesquelles surviennent une croissance et une propagation incontrôlées de cellules anormales.

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