Substituted 1-aminoalkyl-lactams and their use as muscarinic...

Details Substituted 1-aminoalkyl-lactams and their use as muscarinic... Substituted 1-aminoalkyl-lactams and their use as muscarinic...

C - Chemistry, Metallurgy

07

D

C07D 243/08 (2006.01) A61K 31/55 (2006.01) A61K 31/551 (2006.01) A61K 31/553 (2006.01) A61P 1/06 (2006.01) A61P 11/06 (2006.01) A61P 13/06 (2006.01) A61P 21/02 (2006.01) C07D 267/06 (2006.01)

Patent

CA 2408934

This invention relates to compounds which are generally muscarinic M2/M3 receptor antagonists and which are represented by Formula (1) wherein one of X, Y, or Z is independently -S-, -O-, or > N-R4, the others are-CH2-; (p) is an integer from 0 to 3 inclusive; m is an integer from 0 to 3 inclusive; n is an integer from 1 to 6 inclusive; R3 is (C1-6)-alkyl, (C1-6)-alkenyl, (C 1-6)- alkynyl or cycloalkyl; and R1, R2 and R3 are hydrogen or specified substituents. These compounds are useful for treating diseases associated with smooth muscle disorders.

L'invention concerne des composés qui sont généralement des antagonistes de récepteur muscarinique M2/M3 et qui sont représentés par la formule (1) selon laquelle un parmi X, Y, ou Z représente indépendamment -S-, -O-, ou > N-R?4¿, les autres représentant -CH¿2-;? p représente un nombre entier de 0 à 3 compris; m représente un nombre entier de 0 à 3 compris; n représente un nombre entier de 1 à 6 compris; R?3¿ représente alkyle (C¿1-6?), alcényle (C¿1-6?), alkynyle (C¿1-6?) ou cycloalkyle; et R?1¿, R?2¿ et R?3¿ représentent de l'hydrogène ou des substituants spécifiés. Ces composés sont utiles dans le traitement de maladies associées avec des troubles du muscle lisse.

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