Substituted 1-aminoalkyl-lactams and their use as muscarinic...

Details Substituted 1-aminoalkyl-lactams and their use as muscarinic... Substituted 1-aminoalkyl-lactams and their use as muscarinic...

C - Chemistry, Metallurgy

07

D

C07D 243/08 (2006.01) A61K 31/495 (2006.01) A61K 31/55 (2006.01) A61P 1/06 (2006.01) A61P 11/06 (2006.01) A61P 13/06 (2006.01) A61P 21/02 (2006.01) C07D 223/10 (2006.01) C07D 241/08 (2006.01) C07D 267/10 (2006.01) C07D 405/12 (2006.01)

Patent

CA 2409841

This invention relates to compounds which are generally muscarinic M2/M3 receptor antagonists and which are represented by Formula (I) wherein one of X, Y or Z is independently -S-,-0- CH2- or >N-R6, the others are -CH2-; m is an integer from 0 to 3 inclusive; n is an integer from 1 to 6 inclusive; R4 is (C1-6)-alkyl; R5 is independently in each occurrence (C1-6)-alkyl, (C1-6)- alkenyl, (C1-6)- alkynyl or cycloalkyl; and R1, R2, and R3 are hydrogen or specified substituents. These compounds are useful for treating diseases associated with smooth muscle disorders.

L'invention concerne des composés qui sont généralement des antagonistes de récepteur muscarinique M2/M3 et qui sont représentés par la formule (I), selon laquelle, un parmi X, Y ou Z représente indépendamment -S,-0- CH¿2?- ou >N-R?6¿, les autres représentant CH¿2?-; m représente un nombre entier de 0 à 3 compris; n représente un nombre entier de 1 à 6 compris; R?4 ¿ représente alkyle (C¿1-6?); ? ¿R?5¿ ? ¿ représente indépendamment dans chaque occurrence alkyle (C¿1-6?), alcényle (C¿1-6?), alkynyle (C¿1-6?) ou cycloalkyle; et R?1 ¿, R?2 ¿, et R?3¿ représentent de l'hydrogène ou des substituants spécifiés. Ces composés sont utiles dans le traitement de maladies associées à des troubles du muscle lisse.

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