C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/598.7
C07D 303/36 (2006.01)
Patent
CA 1231972
ABSTRACT OF THE DISCLOSURE Preparation and therapeutic activity of 1- arylamino-3-amino-2-propanols, of general formula (I) Image (I) where R represents an isopropyl group in ring position 2 or a methyl group in ring position 4, or an isopropyl group in ring position 2 simultaneously with a methyl group in ring position 5, and where NR1R2 represents an NHC(CH3)3 group, an NHCH(CH3)2 group, or an N(CH3)2 group, and pharmaceutically suitable salts thereof, such as the hydrochlorides. The general preparation of these products is in two steps: the arylamine (II) Image (II) is reacted with epichlorohydrin in a solvent such as ethanol at the boiling point of the solvent, yielding the hydrochloride of (III) Image (III) This hydrochloride, in a solvent such as ethanol and at a temperature equal to or greater than the boiling point of the solvent, yields, with the amine NR1R2, the product of formula (I). The inventive products are employed therapeutically, notably in the treatment of arrhythmias. 114/map
470939
Boyer Chantal
Colleter Jean-Claude
Creuzet Marie-Helene
Feniou Claude
Laguerre Michel
Asta Medica
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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