Substituted 1-oxo- and 1,3-dioxoisoindolines and their use...

Details Substituted 1-oxo- and 1,3-dioxoisoindolines and their use... Substituted 1-oxo- and 1,3-dioxoisoindolines and their use...

C - Chemistry, Metallurgy

07

D

C07D 209/48 (2006.01) A61K 31/4035 (2006.01) A61P 37/00 (2006.01) C07D 209/46 (2006.01)

Patent

CA 2361806

1-Oxo- and 1,3-dioxoisoindolines substituted in the 4- or 5-position of the indoline ring reduce the levels of inflammatory cytokines such as TNF.alpha. in a mammal. A typical embodiment is 4-(4-amino-1,3-dioxoisoindolin-2-yl)-4- carbamoylbutanoic acid.

Selon l'invention, les 1-oxo- et 1,3-dioxoisoindolines substituées en position 4- ou 5- du noyau indoline réduisent les taux de cytokines inflammatoires tels que TNF.alpha. chez un mammifère. Un mode de réalisation typique se présente sous la forme de l'acide 4-(4-amino-1,3-dioxoisoindolin-2-yl)-4-carbamylbutanoïque.

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