Substituted-1-phthalazinamines as vr-1 antagonists

Details Substituted-1-phthalazinamines as vr-1 antagonists Substituted-1-phthalazinamines as vr-1 antagonists

C - Chemistry, Metallurgy

07

D

C07D 401/04 (2006.01) A61K 31/502 (2006.01) A61K 31/5025 (2006.01) C07D 403/04 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2524622

The present invention provides a compound of formula (I): in which Ar and R1 are phenyl or a heteroaromatic group, R2 is generally hydrogen, R3 is hydrogen or alkyl and X, Y and Z are generally CH or N as VR-1 antagonists; or a pharmaceutically acceptable salt thereof; pharmaceutical compositions comprising it; its use in therapy; use of it to manufacture medicaments to treat pain or inflammation; and methods of treating pain or inflammation.

Composé de formule (I) dans laquelle Ar et R?1¿ représentent phényle ou un groupe hétéroaromatique, R?2¿ représente généralement hydrogène, R?3¿ représente hydrogène ou alkyle et X, Y et Z représentent généralement CH ou N, en tant qu'antagonistes de VR-1, ou sel acceptable sur le plan pharmaceutique dudit composé, compositions pharmaceutiques contenant ce composé, son utilisation en thérapie, son utilisation pour produire des médicaments destinés à traiter la douleur ou l'inflammation et méthodes de traitement de la douleur ou de l'inflammation.

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