C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/04 (2006.01)
Patent
CA 2668689
Substituted 3-isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-ol compounds are disclosed that are inhibitors of the vesicular monoamine transporter 2 (VMAT2). The compounds of this invention have the structure (I): wherein R1 is as defined herein, including stereoisomers and pharmaceutically acceptable salts and solvates thereof. Also disclosed are compositions containing a compound of this invention in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use in a subject in need thereof.
L'invention concerne des composés 3-isobutyl-9,10-diméthoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-ol substitués constituant des inhibiteurs du transporteur vésiculaire de monoamines 2 (VMAT2). Les composés de l'invention présentent une structure dans laquelle R1 est tel que défini ici, comprenant des stéréoisomères et des sels et des solvates acceptables d'un point de vue pharmaceutique de ceux-ci. L'invention concerne également des compositions contenant un composé de l'invention combiné à un excipient acceptable d'un point de pharmaceutique, ainsi que des méthodes associées à l'utilisation desdits composés chez un sujet en ayant besoin.
Gowling Lafleur Henderson Llp
Neurocrine Biosciences Inc.
LandOfFree
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