Substituted 1h-benzimidazole-4-carboxamides are potent parp...

C - Chemistry – Metallurgy – 07 – D

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C07D 235/18 (2006.01) A61K 31/4184 (2006.01) A61P 35/00 (2006.01) C07D 409/04 (2006.01) C07D 417/04 (2006.01)

Patent

CA 2628461

Compounds of Formula (I) inhibit the PARP enzyme and are useful for treating a disease or a disorder associated with PARP. Also disclosed are pharmaceutical compositions comprising compounds of Formula (I), methods of treatment comprising compounds of Formula (I), and methods of inhibiting the PARP enzyme comprising compounds of Formula (I).

L~invention concerne des composés répondant à la formule (I) inhibant l~enzyme PARP et utiles dans le traitement d~une pathologie ou d~un trouble associé à PARP. L~invention concerne également des compositions pharmaceutiques comprenant des composés répondant à la formule (I), des procédés de traitement comprenant des composés répondant à la formule (I) et des procédés d~inhibition de l~enzyme PARP comprenant des composés répondant à la formule (I).

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