Substituted 1h-imidazoles

Details Substituted 1h-imidazoles Substituted 1h-imidazoles

C - Chemistry, Metallurgy

07

D

C07D 233/64 (2006.01) A61K 31/415 (2006.01) C07D 233/54 (2006.01) C07D 233/58 (2006.01)

Patent

CA 2165133

Substituted 4-(1,2,3,4-tetrahydro-1-naphtalenyl)-1H-imidazoles and 4-(2,3- dihydro-1H-inden-1-yl)-1H-imidazoles, their optical isomers and their racemic mixtures, their salts, methods for preparing them and therapeutic compositions containing them. These compounds have the general formula Image (I) wherein n = 1 or 2, R1, R2, R3 and R4 = hydrogen, halogen, hydroxyl, C1-C4 alkyl or C1-C4 alkoxy, R5 = hydrogen of C1-C4 alkyl with the proviso that R1, R2, R3, R4 and R5, cannot simultaneously be hydrogen when n is equal to 2. These new compounds exhibit anti-ischemic and anti-hypertensive activities.

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