Substituted 2- [2- (phenyl) ethylamino] alkaneamide...

Details Substituted 2- [2- (phenyl) ethylamino] alkaneamide... Substituted 2- [2- (phenyl) ethylamino] alkaneamide...

C - Chemistry, Metallurgy

07

C

C07C 237/06 (2006.01) A61K 31/165 (2006.01) C07D 295/182 (2006.01)

Patent

CA 2689561

Substituted 2-[2-(phenyl)ethylamino]alkaneamide derivatives of formula (I) wherein X, Y, Z, R, R1, R2, R3, R'3, R4, R5, R6, R7 have the meanings defined in the specification and pharmaceutically acceptable salts thereof, pharmaceutical compositions containing them as active ingredient and their use as sodium and/or calcium channel modulators useful in preventing, alleviating and curing a wide range of pathologies, including, but not limited to, neurological, cognitive, psychiatric, inflammatory, urogenital and gastrointestinal diseases, where the above mechanisms have been described as playing a pathological role.

L'invention porte sur des dérivés substitués de 2-[2-(phényl)éthylamino]alcanamide, représentés par la formule (I) dans laquelle X, Y, Z, R, R1, R2, R3, R'3, R4, R5, R6, R7 ont les significations définies dans la description, et les sels pharmaceutiquement acceptables de ces dérivés, sur des compositions pharmaceutiques les contenant en tant que principe actif et sur leur utilisation en tant que modulateurs des canaux sodiques et/ou calciques, utiles dans la prévention, le soulagement ou la guérison d'une large gamme de pathologies, comprenant, entre autres, des maladies neurologiques, cognitives, psychiatriques, inflammatoires, urogénitales et gastro-intestinales, dans lesquelles les mécanismes ci-dessus ont été décrits comme jouant un rôle pathologique.

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