Substituted 2-amino-fused heterocyclic compounds

Details Substituted 2-amino-fused heterocyclic compounds Substituted 2-amino-fused heterocyclic compounds

C - Chemistry, Metallurgy

07

D

C07D 239/84 (2006.01) A61K 31/47 (2006.01) A61P 3/10 (2006.01) C07D 401/04 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01)

Patent

CA 2651072

The present invention relates to compounds of formula (I), or a pharmaceutically acceptable salt or solvate thereof, wherein: R1, R2, Z1, t, and ring A are as defined in the specification. The invention also relates to pharmaceutical compositions comprising the compounds of formula (I) and methods of treating a condition that is mediated by the modulation of JNK, such as diabetes, the method comprising administering to a mammal an effective amount of a compound of formula (I).

La présente invention a pour objet des composés de formule (I), ou des sels ou solvates de qualité pharmaceutique desdits composés, où : R1, R2, Z1, t et le cycle A sont tels que définis dans la description de l'invention. La présente invention concerne également des compositions pharmaceutiques comprenant les composés de formule (I) et des méthodes de traitement d'un état pathologique faisant intervenir la modulation de JNK, tel que le diabète, la méthode comprenant l'administration à un mammifère d'une quantité efficace d'un composé de formule (I).

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