Substituted 2-aminoacetamides and the use thereof

Details Substituted 2-aminoacetamides and the use thereof Substituted 2-aminoacetamides and the use thereof

A - Human Necessities

61

K

A61K 31/165 (2006.01)

Patent

CA 2310664

This invention is related to substituted 2-aminoacetamides represented by formula (II): or a pharmaceutically acceptable salt or prodrug thereof, wherein the substituents are defined herein. The invention also is directed to the use of substituted 2-aminoacetamides for the treatment of neuronal damage following global and focal ischemia, for the treatment or prevention of neurodegenerative conditions such as amyotrophic lateral sclerosis (ALS), and for the treatment, prevention or amelioration of pain, as anticonvulsants, and as antimanic depressants, as local anesthetics, as antiarrhythmics and for the treatment or prevention of diabetic neuropathy.

L'invention porte sur des 2-aminoacétamides substitués représentés par la formule (II), ou sur un sel pharmaceutiquement acceptable ou un promédicament de ceux-ci, formule dans laquelle les substituants sont définis dans la demande. L'invention porte également sur l'utilisation de 2-aminoacétamides dans le traitement des troubles nerveux dus à une ischémie globale et focale, dans le traitement ou la prévention d'états neurodégénératifs tels que la sclérose latérale amyotrophique, et dans le traitement, la prévention ou l'amélioration de la douleur, sous forme d'anticonvulsifs et d'antidépresseurs anti-maniaco-dépressifs, d'anestésiques locaux, de médicaments antiarythmiques, ainsi que dans le traitement ou la prévention de la neuropathie diabétique.

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