C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/242, 260/328
C07D 333/06 (2006.01) C07D 333/20 (2006.01) C07D 333/28 (2006.01) C07D 333/54 (2006.01) C07D 333/58 (2006.01) C07F 9/50 (2006.01)
Patent
CA 1286681
ABSTRACT The invention provides compounds represented by the general formula Image where R2, R3 and R4 are each selected from the group consisting of H, and OA; is H or -C-R5; R5 is selected O from the group consisting of alkyl and aromatic residues n is 2 or 3; and R1 is selected from the group consisting Image wherein R6 is selected from the group consisting of halogen, hydrocarbyl and hetero atom-substituted hydrocarbyl, comprising from 1 to 12 carbon atoms and wherein said hetero-atoms are selected from the group consisting of halogen, nitrogen, oxygen, sulfur and phosphorus R7 i R6 or H and m equals 1, 2 or 3; with the proviso that at least one of R2, R3 and R4 is H, that at least one of R2, R3 and R4 is not H and that R2 and R4 are not both OA; and pharmaceutically-acceptable salts thereof. The compounds are dopamine receptor agonists and useful for the treatment of glaucoma in mammals.
532095
Gowling Lafleur Henderson Llp
Whitby Research Inc.
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