Substituted 2-benzylamino-2-phenyl-acetamide compounds

Details Substituted 2-benzylamino-2-phenyl-acetamide compounds Substituted 2-benzylamino-2-phenyl-acetamide compounds

C - Chemistry, Metallurgy

07

C

C07C 237/20 (2006.01) A61K 31/165 (2006.01)

Patent

CA 2316082

Compounds which are substituted 2-benzylamino-2-phenyl-acetamide compounds of formula (I) wherein: n is zero, 1, 2 or 3; X is -O-, -S-, -CH2- or -NH-; each of R, R1, R2 and R3, independently, is hydrogen, C1-C6 alkyl. halogen, hydroxy, C1-C6 alkoxy or trifluoromethyl; each of R4 and R5, independently, is hydrogen, C1-C6 alkyl or C3-C7 cycloalkyl; or pharmaceutically acceptable salts thereof, are useful in treating conditions such as chronic or neuropathic pain.

L'invention se rapporte à des composés 2-benzylamino-2-phényl-acétamide substitués qui sont représentés par la formule (I) dans laquelle n est égal à 0, 1, 2 ou 3 ; X est O-, -S-, -CH2- ou NH- ; R, R1, R2 et R3 sont chacun indépendamment hydrogène, alkyle C1-C6, halogène, hydroxy, alcoxy C1-C6 ou trifluorométhyle ; R4 et R5 sont chacun indépendamment hydrogène, alkyle C1-C6 ou cycloalkyle C3-C7. L'invention se rapporte également à des sels pharmaceutiquement acceptables de ces composés qui s'avèrent utiles pour traiter les troubles tels que la douleur chronique ou névropathique.

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