C - Chemistry – Metallurgy – 07 – J
Patent
C - Chemistry, Metallurgy
07
J
C07J 43/00 (2006.01) A61K 31/58 (2006.01)
Patent
CA 2136915
The invention is related to substituted 2.beta.-morpholino- androstane derivatives, bonded at their 2.beta.-position to the nitrogen of a group of formula I Image wherein R represents one to four substituents, each one independently selected from (1-4C) alkyl, phenyl and benzyl, or two at the same carbon atom being together -(CH2)n- wherein n is 2-6; and Y is O or S, or a pharmaceutically acceptable salt thereof. These steroids are very potent intravenous anaesthetics. The compounds have fast onset times and ideal 'sleep duration' vs. 'recovery to full coordination' profiles.
Akzo Nobel Nv
Fetherstonhaugh & Co.
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