Substituted 2-cyclohexyl-4-phenyl-1h-imidazole derivatives

Details Substituted 2-cyclohexyl-4-phenyl-1h-imidazole derivatives Substituted 2-cyclohexyl-4-phenyl-1h-imidazole derivatives

C - Chemistry, Metallurgy

07

D

C07D 403/12 (2006.01) A61K 31/4178 (2006.01) C07D 233/54 (2006.01) C07D 277/22 (2006.01) C07D 401/12 (2006.01) C07D 403/02 (2006.01)

Patent

CA 2403307

Substituted 2-cyclohexyl-4-phenyl-1H-imidazole derivatives capable of modulating NPY5 receptor activity, are provided. Such compounds may be used to modulate NPY binding to NPY5 receptors in vivo or in vitro, and are particularly useful in the treatment of a variety of disorders (e.g., eating disorders such as obesity or bulimia, psychiatric disorders, diabetes and cardiovascular disorders such as hypertension) in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for treating such disorders are provided, as are methods for using such compounds for detecting NPY5 receptors.

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