C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/245.1, 260/2
C07D 311/22 (2006.01) C07D 405/00 (2006.01)
Patent
CA 1115273
Abstract of the Disclosure The invention is compounds of the formula: Image (I) wherein n is zero or l; R1 is hydrogen or C1-C20 alkyl, unsubstituted or substituted by a C2-C5 alkanoyloxy or by a Image group, wherein each of R4 and R5 is independently selected from the group consisting of hydrogen and C1-C10 alkyl, or R4 and R5, taken together with the nitrogen atom form a N-pyrrolidinyl, piperidino or morpholino radical; R2 is C1-C8 alkyl or C3-C4 alkenyl; R3 is (a) furyl, thienyl or pyridyl, the furyl, thienyl and pyridyl groups being unsubstituted or substituted by a methyl group; or (b) the group Image wherein each of R6 and R7 is independently selected from the group consisting of (a') hydrogen; (b') halogen; and (c') the group -(O)n1 -R8, wherein n1 is zero or 1 and R8 is C3-C4 alkenyl or C1-C6 alkyl, the alkenyl and the alkyl groups being unsubstituted or substituted by one or more C1-C2 alkoxy or hydroxy groups. The invention also extends to physiologically acceptable salts of the compounds. The compounds display anti-allergic activity, as evidenced by the fact that they are active in the passive cutaneous anaphylaxis t?st in rats.
308526
Corno Maria L.
Doria Gianfederico
Lauria Francesco
Romeo Ciriaco
Sberze Piero
Farmitalia Carlo Erba S.p.a.
Fetherstonhaugh & Co.
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