Substituted 2-indolinone as ptk inhibitors containing a zinc...

Details Substituted 2-indolinone as ptk inhibitors containing a zinc... Substituted 2-indolinone as ptk inhibitors containing a zinc...

C - Chemistry, Metallurgy

07

D

C07D 403/06 (2006.01) A61K 31/404 (2006.01)

Patent

CA 2663147

The present invention relates to substituted 2-indolinone containing zinc- binding moiety based derivatives that have enhanced or unique properties as inhibitors of protein tyrosine kinase (PTK) receptors and their use in the treatment of PTK related diseases and disorders such as cancer. The said derivatives may further act as HDAC inhibitors.

La présente invention concerne une 2-indolinone substituée contenant des dérivés basés sur une fraction se liant au zinc qui présentent des propriétés uniques ou améliorées en tant qu'inhibiteurs des récepteurs de la tyrosine kinase de protéine (PTK), et l'utilisation desdits dérivés dans le traitement de maladies et de troubles liés à la PTK, tels que le cancer. Lesdits dérivés peuvent en outre agir en tant qu'inhibiteurs de HDAC.

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