Substituted 2-phenylamino-imidazolines-(2), their acid...

Details Substituted 2-phenylamino-imidazolines-(2), their acid... Substituted 2-phenylamino-imidazolines-(2), their acid...

C - Chemistry, Metallurgy

07

D

260/314.7

C07D 233/50 (2006.01)

Patent

CA 1085861

ABSTRACT OF THE DISCLOSURE This invention relates to novel derivatives of 2-phenyl- amino-imidazoline-(2) having the formula I I Image [wherein R1, R2 and R3, which may be the same or different, each represents a hydrogen, fluorine, chlorine or bromine atom or a methyl, ethyl, methoxy, hydroxy, trifluoromethyl or cyano group; and R4 represents a group of the formula Image (in which n is an integer from 2 to 5)]. These compounds have interesting pharmacological properties. In particular, the novel compounds exhibit analgesic and bradycardiac activities and may therefore be useful in the treatment of pain and/or coronary disease. Processes for the preparation of the novel compounds are described and exemplified, and examples of pharmaceutical compositions containing the novel compounds are given.

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