Substituted 2-phenylimino-imidazolidines, their acid...

Details Substituted 2-phenylimino-imidazolidines, their acid... Substituted 2-phenylimino-imidazolidines, their acid...

C - Chemistry, Metallurgy

07

D

260/315

C07D 233/50 (2006.01)

Patent

CA 1115717

ABSTRACT OF THE DISCLOSURE Compounds of general formula Image (wherein R represents a 2-bromo-4,5-dihydroxyphenyl, 3-chloro-4-hydroxyphenyl, 4 bromo-2,5-dihydroxyphenyl, 3,5-dihydroxyphenyl, 5-chloro-2,4-dihydroxyphenyl, 3-hydroxy-4-methylphenyl, 2,6-dibromo-4-hydroxy- methylphenyl, 3,5-dibromo-4-aminophenyl, 3-methyl- mercaptophenyl, 3,4,5-trihydroxyphenyl or 3-bromo-4- fluorophenyl group) and acid addition salts thereof. The novel compounds exhibit a strong bradycardiac activity and may therefore be useful in the treatment of coronary disease. Processes for the preparation of the novel compounds and their use in pharmaceutical compositions are described and exemplified

321805

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