Substituted 2-vinyl-chromones and process for their preparation

Details Substituted 2-vinyl-chromones and process for their preparation Substituted 2-vinyl-chromones and process for their preparation

C - Chemistry, Metallurgy

07

D

260/356.1, 260/2

C07D 311/22 (2006.01) C07D 407/06 (2006.01)

Patent

CA 1107291

ABSTRACT OF THE DISCLOSURE This invention relates to the compounds of the invention having the following formula (I) Image (I) wheroin n is zero or 1; R is hydrogen or C1-C12 alkyl, unsubstituted or sub- stituted by a C2-C5 alkanoyloxy or by a Image group, wherein each of R4 and R5 is independently selected from the group consisting of hydrogen and C1-C10 alkyl; R1 is C2-C4 alkyl or C3-C4 alkenyl; R2 is hrdrogen or methyl; R3 is (a) furyl, thienyl or pyridyl, being the furyl, thienyl and pyridyl groups unsubstituted or substituted by a methyl group; or (b) the group Image wherein each of R6 and R7 is independently selected from the group consisting of (a') hydrogen; (b') halogen; and (c') the group -(O)n1-R8, wherein n1 is zero or 1 snd R8 is C3-C4 alkenyl or C1-C4 alkyl, being the alkenyl and the alkyl groups unsubstituted or substituted by one or more C1-C2 alkoxy or hydroxy groups; W is Image or Image , and pharracouticallt acceptable salts thereof. It also relates to a process for the preparation of such compounds. The coopounds of formula I and their salts possess anti- allergic activity and can therefore be used in the prevention snd treatment of bronchial asthma, allergic rhinitis, hay fever, urticaria and dermatosis.

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