Substituted 3-(2,5 -disubstituted) pyridyl-4-aryl pyrroles...

Details Substituted 3-(2,5 -disubstituted) pyridyl-4-aryl pyrroles... Substituted 3-(2,5 -disubstituted) pyridyl-4-aryl pyrroles...

C - Chemistry, Metallurgy

07

D

C07D 413/14 (2006.01) A61K 31/4439 (2006.01) A61K 31/496 (2006.01) A61K 31/506 (2006.01) C07D 401/04 (2006.01) C07D 401/14 (2006.01) C07D 403/04 (2006.01) C07D 471/04 (2006.01) C07D 487/04 (2006.01)

Patent

CA 2500221

This invention provides novel substituted 3-(2,5-disubstituted)pyridyl-4-aryl pyrroles, and pharmaceutical compositions comprising same, useful for treating disorders ameliorated by reducing TNF-.alpha. production and/or p38 activity in appropriate cells. This invention also provides therapeutic and prophylactic methods using the instant pharmaceutical compositions.

L'invention concerne de nouveaux 3-(2,5-disubstitué)pyridyl-4-aryl pyrolles substitués et des compostions pharmaceutiques renfermant ceux-ci, utiles pour le traitement de troubles améliorés par réduction de la production de TNF-.alpha. et/ou de l'activité p38 dans des cellules appropriées. L'invention concerne également des méthodes thérapeutiques et prophylactiques mettant en oeuvre les compositions pharmaceutiques selon l'invention.

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