Substituted 3,4-dihydronaphthalenes, pharmaceutical...

Details Substituted 3,4-dihydronaphthalenes, pharmaceutical... Substituted 3,4-dihydronaphthalenes, pharmaceutical...

C - Chemistry, Metallurgy

07

C

C07C 275/64 (2006.01) A61K 31/16 (2006.01) C07C 259/06 (2006.01)

Patent

CA 2070495

Abstract Substituted 3,4-dihydronaphthalenes of the formula I Image wherein R1 is the methyl or the amino group, R2 represents a hydrogen atom or the methyl group and R3 is a linear or branched chain alkyl residue having 1 to 4 carbon atoms, the allyl or the crotyl residue or a cyclopentyl group are disclosed which specifically inhibit 5-lipoxygenase and are useful in pharmaceutical compositions for prophylaxis and treatment of diseases due to the action of leukotrie- nes. The dihydronaphthalenes may be prepared by reacting a compound of formula II Image with hydroxylamine or a salt thereof to form the corre- sponding oxime, reducing the oxime to a hydroxylamine of formula III Image and introducing the residue -CO-R1.

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