Substituted 3-alkyl and 3-arylalkyl 1h-indol-1-yl acetic...

Details Substituted 3-alkyl and 3-arylalkyl 1h-indol-1-yl acetic... Substituted 3-alkyl and 3-arylalkyl 1h-indol-1-yl acetic...

C - Chemistry, Metallurgy

07

D

C07D 209/10 (2006.01) A61K 31/404 (2006.01) A61P 43/00 (2006.01) C07D 409/06 (2006.01)

Patent

CA 2509170

The invention formula (1) substituted 3-alkyl and 3 arylalkyl 1H indol-1yl acetic acid derivatives which are useful as inhibitors of plasminogen activator inhibitor (PAI-1) useful for treating fibrinolytic disorders, the compounds having the structure wherein: R1, R2, R3, R4, R5, R6, and R7 are as defined herein or a pharmaceutically acceptable salt or ester form thereof.

La présente invention a trait à des dérivés substitués de l'acide acétique de 3-alkyle et 3-arylalkyle 1H-indol-1-yle utiles en tant qu'inhibiteurs de l'inhibiteur des activateurs du plasminogène (PAI1), utiles pour le traitement de troubles fibrinolytiques, les composés présentant une structure dans laquelle : R¿1?, R¿2?, R¿3?, R¿4?, R¿5?, R¿6?, et R¿7? sont tels que définis dans la description ou un sel ou ester pharmaceutiquement acceptables de ceux-ci.

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