Substituted 3-amino-thieno[2,3-b] pyridine-2-carboxamide...

Details Substituted 3-amino-thieno[2,3-b] pyridine-2-carboxamide... Substituted 3-amino-thieno[2,3-b] pyridine-2-carboxamide...

C - Chemistry, Metallurgy

07

D

C07D 495/04 (2006.01) A61K 31/4365 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01)

Patent

CA 2653654

Disclosed are compounds of formula (I): (I) wherein R1 and R4 are defined herein, which are useful as inhibitors of the kinase activity of the I.kappa.B kinase (IKK) complex. The compounds are therefore useful in the treatment of IKK mediated diseases including autoimmune diseases inflammatory diseases, cardiovascular disease and cancer. Also disclosed are pharmaceutical compositions comprising these compounds and processes for preparing these compounds.

La présente invention concerne des composés répondant à la formule (I), R1 et R4 étant tels que définis dans ce document, qui se révèlent utiles en tant qu'inhibiteurs de l'activité kinase du complexe I.kappa.B kinase (IKK). Les composés s'avèrent en conséquence utiles pour le traitement de maladies induites par le IKK, incluant les maladies auto-immunes, les maladies inflammatoires, les maladies cardiovasculaires et le cancer. L'invention concerne également des compositions pharmaceutiques contenant ces composés et des procédés permettant de préparer ces composés.

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