C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 495/04 (2006.01) A61K 31/4365 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2548011
Disclosed are compounds of formula (I): wherein the variables R1, R2, R3 and Z are described herein, which are useful as inhibitors of the kinase activity of the I.kappa.B kinase (IKK) complex. The compounds are therefore useful in the treatment of IKK mediated diseases including autoimmune diseases inflammatory diseases and cancer. Also disclosed are pharmaceutical compositions comprising these compounds and processes for preparing these compounds.
L'invention concerne des composés de formule (I). Dans cette formule, les variables R¿1?, R¿2?, R¿3? et Z sont décrites dans la description. Les composés de l'invention sont utiles en tant qu'inhibiteurs de l'activité de la kinase du complexe de kinase I.kappa.B (IKK). Les composés de l'invention sont par conséquent utiles dans le traitement de maladies médiées par IKK, notamment des maladies auto-immunes, des maladies inflammatoires et le cancer. L'invention concerne des compositions pharmaceutiques comprenant ces composés, et des procédés pour préparer ces composés.
Chen Zhidong
Cirillo Pier Francesco
Disalvo Darren
Liu Weimin
Marshall Daniel Richard
Boehringer Ingelheim Pharmaceuticals Inc.
Fetherstonhaugh & Co.
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