Substituted 3-cyanopyridines as protein kinase inhibitors

Details Substituted 3-cyanopyridines as protein kinase inhibitors Substituted 3-cyanopyridines as protein kinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 213/85 (2006.01) A61K 31/465 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 405/12 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01) C07D 413/14 (2006.01) C07D 417/12 (2006.01) C07D 417/14 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2654515

The present teachings provide compounds of formula I or a pharmaceutically acceptable salt, hydrate, or ester thereof, wherein: X is selected from a) -NR3-Y-, b) -O-Y-, c) -S(O)m-Y-, d) -S(O)mNR3- Y-, e) -NR3S(O)m-Y-, f) -C(O)NR3-Y-, g) -C(S)NR3-Y-, h) -NR3C(O)- Y-, i) -NR3C(S)-Y-, j) -C(O)O-Y-, k) -OC(O)-Y-, and I) a covalent bond; Y, at each occurrence, independently is selected from a) a divalent C1-10 to alkyl group, b) a divalent C2-10 alkenyl group, c) a divalent C2-10 alkynyl group, d) a divalent C1-10 haloalkyl group, and e) a covalent bond; R1 is selected from a) a C 1-10 alkyl group, b) a C3-14cycloalkyl group, c) a 3-14 membered cycloheteroalkyl group, d) a C8-14 polycyclic aryl group and e) a 5-14 membered heteroaryl group, wherein each group optionally is substituted with 1-4 -Y-R4; R2 is a C6-14 aryl group or a 5-14 membered heteroaryl group, wherein each group optionally is substituted with 1-4 groups independently selected from -Y-R4 Or -O-Y-R4. The present teachings also provide methods of making the compounds of formula I, and methods of treating autoimmune and inflammatory diseases by administering a therapeutically effective amount of a compound or compounds of formula I to a mammal including a human.

La présente invention concerne des composés représentés par la formule I et leurs sels, hydrates et esters pharmaceutiquement acceptables, formule dans laquelle R1, R2 et X sont tels que définis ici. La présente invention concerne également des procédés de fabrication des composés représentés par la formule I, et des procédés de traitement de maladies auto-immunes et inflammatoires par l'administration d'une quantité thérapeutiquement efficace d'un composé ou de composés représentés par la formule I à un mammifère, y compris à l'humain.

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