Substituted 3-cyanoquinolines as protein tyrosine kinases...

Details Substituted 3-cyanoquinolines as protein tyrosine kinases... Substituted 3-cyanoquinolines as protein tyrosine kinases...

C - Chemistry, Metallurgy

07

D

C07D 401/12 (2006.01) A61K 31/47 (2006.01) C07D 215/00 (2006.01) C07D 215/54 (2006.01) C07D 221/00 (2006.01) C07D 317/00 (2006.01) C07D 319/00 (2006.01) C07D 401/14 (2006.01) C07D 405/12 (2006.01) C07D 405/14 (2006.01) C07D 409/12 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01) C07D 491/04 (2006.01) C07D 491/10 (2006.01)

Patent

CA 2344169

This invention provides compounds of formula (1) wherein R1, G1, G2, R4, Z, X and n are defined herein, or a pharmaceutically acceptable salt thereof, which are useful as antineoplastic agents and in the treatment of polycystic kidney disease.

La présente invention concerne des composés représentés par la formule générale (1) ou certains de leurs sels pharmaceutiquement admis. Cette formule correspond à une structure où R¿1?, G¿1?, G¿2?, R¿4?, Z, X et n sont tels que décrits dans cette demande internationale. Ces composés, ou les sels considérés, conviennent d'une part comme antinéoplasiques et d'autre part pour le traitement de la polykystose rénale.

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