C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
260/487.2, 260/5
C07C 243/38 (2006.01)
Patent
CA 1249299
ABSTRACT OF THE DISCLOSURE Substituted 3-hydrazinopropionates comprising compounds of the general formula: Image wherein R1, R2 = H, an alkyl, a substituted alkyl, hydroxy- carbonyl, alkoxycarbonyl, an aryl, an aralkyl, an unsatura- ted alkyl, a substituted aryl or a substituted aralkyl: Image wherein R7, R8 = H, an alkyl, an unsaturated alkyl, an aralkyl, an aryl, a substituted alkyl, R9 = OH, an alkoxy, an aralkoxy, an alkyl, an unsaturated alkyl, an aryl, a substituted aryl, an aralkyl; R4 is -C?N, -COR10, wherein R10 = OR11, NR12R13, where R11 is H, an alkyl, an aralkyl and an alkali metal, R11 and R12 are each H, an alkyl, an aralkyl, an aryl; R5, R6= an alkyl, an aryl, an aralkyl. These compounds possess an antiarrhythmic activity and are useful in medicine for the treatment of heart beat disturbances. The preparation of the compounds is also disclosed.
458748
Antsena Irene B.
Bremanis Gunar A.
Kalvinsh Ivars Y.
Kauss Valeryans Y.
Liepinsh Edvards E.
Institut Organicheskogo Sinteza Akademii Nauk Latviiskoi Ssr
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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