C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/12 (2006.01) A61K 31/44 (2006.01) A61K 31/535 (2006.01) A61K 31/55 (2006.01) C07D 401/14 (2006.01) C07D 409/12 (2006.01) C07D 409/14 (2006.01) C07D 413/12 (2006.01) C07D 413/14 (2006.01) C07D 417/12 (2006.01)
Patent
CA 2066332
Substituted 3-(Pyridinylamino)-indoles and benzo[b]thiophenes a process for their preparation and their use as medicaments The present invention relates to compounds of the formula I (see formula I) where R1 is hydrogen, loweralkyl, loweralkenyl, loweralkynyl, arylloweralkyl, aminoloweralkyl, loweralkylaminoloweralkyl, formyl, loweralkylcarbonyl, aminoloweralkylcarbonyl or loweralkoxycarbonyl; the group -X-Y= is Image , R2 and R3 being independently hydrogen or loweralkyl; W is hydrogen, halogen, hydroxy, loweralkoxy, arylloweralkoxy or Image , where R4 is hydrogen, loweralkyl or arylloweralkyl; R5 is loweralkyl or arylloweralkyl; or alternatively the group Image R6 being hydrogen, loweralkyl, aryl or arylloweralkyl; and Z is hydrogen, halogen, loweralkyl, nitro or amino; which are useful for alleviating various memory dysfunctions such as Alzheimer's disease, as modulators of neurotransmitter functions such as serotonergic and adrenergic, and as such are useful as antidepressants, anxiolytics, atypical antipsychotics, antiemetics, and for the treatment of personality disorders such as obsessive compulsive disorders.
Effland Richard Charles
Klein Joseph Thomas
Martin Lawrence Leo
Aventis Pharmaceuticals Inc.
Bereskin & Parr
Hoechst-Roussel Pharmaceuticals Inc.
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