C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/04 (2006.01) A61K 31/4427 (2006.01) A61K 31/506 (2006.01) A61P 29/00 (2006.01) C07D 401/14 (2006.01) C07D 403/04 (2006.01) C07D 409/14 (2006.01)
Patent
CA 2374559
This invention provides novel substituted 3-pyridyl-4-arylpyrroles, having chemical structure (I) and pharmaceutical compositions comprising same, useful for treating disorders ameliorated by reducing TNF-.alpha. production and/or p38 activity in appropriate cells. This invention also provides therapeutic and prophylactic methods using the instant pharmaceutical compositions.
La présente invention concerne des nouveaux 3-pyridyle-4-arylpyrroles substitués, correspondant à la structure chimique suivante (I). L'invention concerne également des compositions pharmaceutiques comprenant ces nouveaux 3-pyridyle-4-arylpyrroles substitués. Lesquelles compositions sont utilisées pour traiter plus efficacement les troubles, par réduction de la production de facteurs de nécrose des tumeurs et/ou de l'activité du p38 dans des cellules appropriées. L'invention concerne également des méthodes prophylactiques et thérapeutiques utilisant lesdites compositions pharmaceutiques.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
Ortho-Mcneil Pharmaceutical Inc.
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