C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/04 (2006.01) A61K 31/4985 (2006.01) A61P 25/28 (2006.01)
Patent
CA 2520251
The invention relates to substituted 4-amino[1,2,4]triazolo[4,3-a]quinoxalines of formula (I) the prodrugs thereof, and the pharmaceutically acceptable salts of the compounds and produgs, wherein Ra, Rb, R1, and R2 are as defined herein; compositions thereof; which are inhibitors of glycogen sythase knase- 3(GSK-3) and, as such, are useful in the treatment of, inter alia, conditions, diseases, and symptoms such as diabetes, dementia, Alzheimer~s Disease, bipolar disorder, stroke, schizophrenia, depression, hair loss, cancer, and the like.
L'invention se rapporte à des 4-amino[1,2,4]triazolo[4,3-a]quinoxalines substituées répondant à la formule (I), à leurs promédicaments et aux sels pharmaceutiquement acceptables de ces composés et promédicaments, R?a¿, R?b¿, R?1¿ et R?2¿ étant tels que définis, et à des compositions les contenant. Ces composés sont des inhibiteurs de la glycogène synthase kinase-3(GSK-3) et, en tant que tels, utiles dans le traitement, entre autres, d'états pathologiques, de maladies et de symptômes tels que le diabète, la démence, la maladie d'Alzheimer, les troubles bipolaires, les attaques, la schizophrénie, la dépression, l'alopécie, le cancer, et affections analogues.
Benbow John William
Chu-Moyer Margaret Yuhua
Kung Daniel Wei-Shung
Pfizer Products Inc.
Smart & Biggar
LandOfFree
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