Substituted 4-amino-1-(pyridylmethyl) piperidine as...

Details Substituted 4-amino-1-(pyridylmethyl) piperidine as... Substituted 4-amino-1-(pyridylmethyl) piperidine as...

C - Chemistry, Metallurgy

07

D

C07D 401/14 (2006.01) A61K 31/4545 (2006.01) A61P 13/10 (2006.01)

Patent

CA 2500800

This invention provides 4-amino-1-(pyridylmethyl) piperidine of formula (I) and related compounds and pharmaceutically acceptable salts thereof which are useful as muscarinic receptor antagonists. This invention also provides pharmaceutical compositions containing such compounds; processes and intermediates useful for preparing such compounds; and methods for treating disease conditions mediated by muscarinic receptors, such as overactive bladder, irritable bowel syndrome and chronic obstructive pulmonary disease, using such compounds.

L'invention concerne une 4-amino-1-(pyridylméthyl) piperidine de la formule (I) et des composés associés, ainsi que des sels acceptables sur le plan pharmaceutique de ceux-ci, lesquels sont utiles comme antagonistes des récepteurs muscariniques. L'invention concerne également des compositions pharmaceutiques renfermant de tels composés; des procédés et des intermédiaires utiles pour la préparation de tels composés; et des méthodes de traitement d'états pathologiques induits par des récepteurs muscariniques, tels que la vessie hyperactive, le syndrome du côlon irritable et une maladie obstructive respiratoire, au moyen de tels composés.

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