Substituted 4-aminomethylene-chromans and -chromenes,...

Details Substituted 4-aminomethylene-chromans and -chromenes,... Substituted 4-aminomethylene-chromans and -chromenes,...

C - Chemistry, Metallurgy

07

D

260/353.3, 260/3

C07D 311/58 (2006.01) C07D 311/60 (2006.01) C07D 311/96 (2006.01) C07D 405/12 (2006.01) C07D 407/12 (2006.01) C07F 7/18 (2006.01)

Patent

CA 1221700

ABSTRACT OF THE DISCLOSURE The invention relates to substituted 4-aminomethylene- chromans and chromenes of Formula (I) infra, as well as methods for making of said chromans and chromenes,compositions containing said chromans and chromenes and methods for the use of said chromans, chromenes and compositions containing said chromans and chromenes. The compounds and compositions of the invention are useful for their circulation influencing activity: (I) Image in which -A- is a single or double bond, R1 and R2 are H, alkyl, cycloalkyl, aryl or aralkyl, or R1 and R2 together with the adjacent carbon atom form a carbocyclic ring, R3-R6 are H, hydroxyl, halogen, alkyl, cycloalkyl, aryl, aralkyl, alkoxy, aryloxy or aralkoxy, R7-R8 are H or alkyl, X is a single bond, methylene, O or NR17, R17 is H or alkyl or R17 together with R7 form an alkylene R12-R16 are H, hydroxyl, halogen, alkyl, cycloalkyl, aryl, aralkyl, alkoxy, aryloxy, aralkoxy or trifluoromethyl, or R12 and R13 or R13 and R14 together form alkylenedioxy or -CH=CH-CH=CH-.

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