Substituted 4-aryl-4h-pyrrolo[2,3-h]chromenes and analogs as...

Details Substituted 4-aryl-4h-pyrrolo[2,3-h]chromenes and analogs as... Substituted 4-aryl-4h-pyrrolo[2,3-h]chromenes and analogs as...

C - Chemistry, Metallurgy

07

D

C07D 401/00 (2006.01) A61K 31/44 (2006.01) C07D 235/02 (2006.01) C07D 491/04 (2006.01)

Patent

CA 2484702

The present invention is directed to substituted 4H-chromenes and analogs thereof, represented by the Formula (I): wherein R1~, R3~-R5~, A, D, Y and Z are defined herein. The present invention also relates to the discovery that compounds having Formula (I) are activators of caspases and inducers of apoptosis. Therefore, the activators of caspases and inducers of apoptosis of this invention can be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.

La présente invention concerne 4<i>H</i>-chromènes substitués et des analogues correspondants, représentés par la formule I, dans laquelle R<1>, R<3>-R<5>, A, D, Y et Z sont définis. Cette invention a également trait au fait que ces composés de formule I sont des activateurs de caspases et des inducteurs d'apoptose. De ce fait, les activateurs de caspases et les inducteurs d'apoptose de ladite invention peuvent être utilisés pour induire la mort cellulaire dans divers troubles cliniques qui se caractérisent par l'apparition d'une croissance incontrôlée et d'un développement de cellules anormales. < >

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