C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 311/58 (2006.01) A61K 31/352 (2006.01)
Patent
CA 2656706
The present invention is directed to a substituted 4H-chromene represented by the Formula (1R), substantially free from the corresponding (S)-stereoisomer: The present invention also relates to the discovery that compound 1R, substantially free from the corresponding (S)-stereoisomer, is an activator of caspases and inducer of apoptosis, as well as an antivascular agent. Therefore, compound 1R, substantially free from the corresponding (S)-stereoisomer, can be used to induce cell death in a variety of clinical conditions in which uncontrolled growth, and spread of abnormal cells occurs. Compound 1R, substantially free from the corresponding (S)-stereoisomer, also can be used for the treatment of diseases due to overgrowth of vasculature, such as solid tumors and ocular neovascularization.
Cette invention concerne un 4H-chromène substitué représenté par la formule 1R, qui est sensiblement exempt du (S)-stéréoisomère correspondant. L'invention concerne également la découverte selon laquelle un composé 1R sensiblement exempt du (S)-stéréoisomère correspondant est un activateur de capsases et un inducteur d'apoptose, ainsi qu'un agent anti-vascularisation. Dans ces conditions, le composé 1R sensiblement exempt du (S)-stéréoisomère correspondant peut s'utiliser pour induire la mort cellulaire dans divers états cliniques s'accompagnant d'une croissance sauvage et d'une dissémination de cellules anormales. Le composé 1R sensiblement exempt du (S)-1stéréoisomère correspondant peut être également utilisé pour le traitement de maladies dues à une vascularisation excessive, tels que des tumeurs solides ou une néovascularisation oculaire.
Blais Charles
Cai Sui Xiong
Drewe John A.
Gourdeau Henriette
Kasibhatla Shailaja
Cytovia Inc.
Mbm Intellectual Property Law Llp
LandOfFree
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