Substituted 4-(indazol-3-yl)phenols as estrogen receptor...

Details Substituted 4-(indazol-3-yl)phenols as estrogen receptor... Substituted 4-(indazol-3-yl)phenols as estrogen receptor...

C - Chemistry, Metallurgy

07

D

C07D 231/56 (2006.01) A61K 31/416 (2006.01) A61P 3/06 (2006.01) A61P 5/26 (2006.01) A61P 19/02 (2006.01) A61P 25/28 (2006.01) A61P 29/00 (2006.01) C07D 409/04 (2006.01)

Patent

CA 2499736

This invention provides compound of formulae I or II having the structure wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, and R10 are as defined in the specification or a pharmaceutically acceptable salt thereof which are useful for the treatment of the inflammatory component of diseases and are particularly useful in treating atherosclerosis, myocardial infarction, congestive heart failure, inflammatory bowel disease. Arthritis, type II diabetes, and autoimmune diseases such as multiple sclerosis and rheumatiod arthritis.

Cette invention a trait à un composé, correspondant à la formule (I ou II) et ayant la structure présentée ci-dessous, ou à un sel de celui-ci, acceptable du point de vue pharmaceutique. Ceux-ci se révèlent des plus utiles pour lutter contre la substance provoquant une inflammation dans certaines maladies ainsi que pour traiter l'athérosclérose, l'infarctus du myocarde, les insuffisances cardiaques globales, les affections intestinales inflammatoires, l'arthrite, le diabète de type II ainsi que des maladies auto-immunes telles que la sclérose en plaques et la polyarthrite rhumatoïde. Dans cette formule, R¿1?, R2, R¿3, ?R¿4?, R¿5?, R¿6?, R¿7?, R¿8?, R¿9? et R¿10 ?sont tels que définis dans le descriptif.

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