Substituted 4-(indazolyl)-1,4-dihydropyridines and methods...

Details Substituted 4-(indazolyl)-1,4-dihydropyridines and methods... Substituted 4-(indazolyl)-1,4-dihydropyridines and methods...

C - Chemistry, Metallurgy

07

D

C07D 401/04 (2006.01) A61K 31/4422 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2727204

This invention relates to novel 4-(indazolyl)-1,4-dihydropyridine og the following formula (I) derivatives having protein tyrosine kinase inhibitory activity, to a process for the manufacture thereof and to the use thereof for the treatment of c-Met-mediated diseases or c-Met- mediated conditions, particularly cancer and other proliferative disorders.

La présente invention concerne de nouveaux dérivés de la 4-(indazolyl)-1,4-dihydropyridine de formule (I) suivante ayant une activité inhibitrice des protéines tyrosine kinases, un procédé pour leur fabrication et leur utilisation dans le traitement de maladies médiées par c-Met ou détats médiés par c-Met, particulièrement le cancer et dautres affections prolifératives.

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