C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/259
C07D 403/12 (2006.01) C07D 233/44 (2006.01) C07D 239/30 (2006.01) C07D 239/36 (2006.01) C07D 239/42 (2006.01)
Patent
CA 1138454
ABSTRACT OF THE DISCLOSURE The specification discloses substituted 5-(2- imidazoline-2-yl)-aminopyrimidines of general formula (I) Image (I) wherein R1, R2 and R3, which can be the same or different, are a hydrogen or a halogen atom, or an alkoxy-, alkylthio- or alkyl group with 1 to 4 carbon atoms or a cycloalkyl group with 3 to 5 carbon atoms, and R4 is a hydrogen atom or an aliphatic or aromatic acyl group; and their physiologically acceptable acid addition salts, as well as the method for the production of said compounds and their application in pharmaceutical preparations. These substances and their physiologically acceptable acid addition salts possess valuable therapeutic properties. In particular, they are characterized by blood pressure reducing effects and are thus suitable for treatment of hypertension. Furthermore, the substances can be used in treatment of glaucoma.
339844
Armah Ben
Cohnen Erich
Fleck Wolfgang
Stenzel Wolfgang
Beiersdorf Aktiengesellschaft
Gowling Lafleur Henderson Llp
LandOfFree
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