C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 239/34 (2006.01) A61K 31/505 (2006.01) A61P 3/10 (2006.01) A61P 25/00 (2006.01) A61P 25/28 (2006.01) C07D 239/38 (2006.01) C07D 239/42 (2006.01) C07D 239/46 (2006.01) C07D 239/48 (2006.01) C07D 401/04 (2006.01) C07D 405/04 (2006.01) C07F 9/6512 (2006.01)
Patent
CA 2416442
The present invention relates to a series of novel substituted 5-alkynyl pyrimidines, pharmaceutical compositions which contain them, methods for their preparation, and their use in therapy, particularly in the treatment of neurodegenerative or other neurological disorders of the central and peripheral nervous systems, including age related cognitive disorders such as senility and Alzheimer's disease, nerve injuries, peripheral neuropathies, and seizure disorders such as epilepsy.
Cette invention se rapporte à une série de nouvelles 5-alkynyle pyrymidines substituées, à des compositions pharmaceutiques qui les contiennent, à des procédés pour leur préparation et à leur utilisation à des fins thérapeutiques, notamment dans le traitement des affections neurodégénératives ou d'autres affections neurologiques des systèmes nerveux central et périphérique, y compris les troubles cognitifs liés à l'âge, tels que la sénilité et la maladie d'Alzheimer, les lésions des nerfs, les neuropathies périphériques et les affections avec spasmes, telles que l'épilepsie.
Beauchamp Lilia
Kelley James L.
Krenitsky Thomas A.
Krenitsky Pharmaceuticals Inc.
Smart & Biggar
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