Substituted 5-ring heterocycles, their preparation and their...

Details Substituted 5-ring heterocycles, their preparation and their... Substituted 5-ring heterocycles, their preparation and their...

C - Chemistry, Metallurgy

07

K

C07K 5/06 (2006.01) A61K 31/41 (2006.01) A61K 31/675 (2006.01) A61K 38/05 (2006.01) C07D 233/36 (2006.01) C07D 233/76 (2006.01) C07D 263/44 (2006.01) C07D 277/34 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 405/12 (2006.01) C07K 5/02 (2006.01) C07K 5/078 (2006.01) C07K 5/097 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2169643

The present invention relates to 5-membered ring hetero- cycles of the general formula I, Image (I) in which W, Y, Z, B, D, E and R, and also b, c, d, e, f, g and h, have the meaning given in the description, to processes for their preparation and to their use as inhibitors of thrombocyte aggre- gation, the metastasization of carcinoma cells, and also the binding of osteoclasts to the bone surface.

L'invention concerne des hétérocycles à 5 noyaux de la formule générale (I), dans laquelle W, Y, Z, B, D, E et R, ainsi que b, c, d, e, f, g et h ont la notation mentionnée dans la description. L'invention concerne également des procédés permettant de les préparer et de les utiliser comme substances inhibant l'agrégation thrombocytaire, la production de métastases par des cellules cancéreuses, ainsi que la fixation d'ostéoclastes à la surface des os.

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