C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 237/20 (2006.01) A61K 31/501 (2006.01) A61P 3/04 (2006.01) C07D 237/22 (2006.01) C07D 401/12 (2006.01)
Patent
CA 2729313
The present invention is concerned with novel substituted 6-(1-piperazinyl)- pyridazines of Formula (I) wherein R 1, R 2, R 3 and X have the meaning defined in the claims, having 5 -HT 6- antagonistic properties. The invention further relates to pro-cesses for preparing such novel compounds, pharmaceutical compositions comprising said novel compound as an active ingredi-ent as well as the use of said compounds as a medicine.
La présente invention concerne de nouvelles 6-(1-pipérazinyl)-pyridazines substituées de Formule (I) dans laquelle R1, R2, R3 et X ont les significations définies dans les revendications, qui ont des propriétés antagonistes de 5-HT6. L'invention concerne en outre des procédés de préparation de ces nouveaux composés, des compositions pharmaceutiques comprenant un desdits nouveaux composés comme ingrédient actif, ainsi que des utilisations desdits composés comme médicaments.
Bartolome-Nebreda Jose Manuel
Conde-Ceide Susana
Delgado-Jimenez Francisca
Macdonald Gregor James
Van Gool Michiel Luc Maria
Gowling Lafleur Henderson Llp
Janssen Pharmaceutica Nv
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